Use of is/are in sentences where you talk about two things - one singular and other plural

This recently came up when chatting with a colleague who moved companies. I asked "How is your manager and teammates?"

Later I thought if I should've used "How are your manager and teammates?"

Which one is correct?


It does not matter that one is singular and the other is plural; it matters that the whole group of them are more than one person. "How are Nancy and Sakura?"