Can I use the past perfect with present perfect in English
Solution 1:
There are some common combinations of tense constructions in consecutive clauses. But there is no rule that prohibits the past perfect in a clause following a clause containing a present perfect. Indeed, just about any consecutive clauses can contain any verb construction.
In your case, the most likely context suggests the present perfect in both clauses:
He has informed me that you have approved his request for a loan.
But the past perfect is feasible in the following context:
He has informed me that you had approved his request for a loan, but changed your mind the following day.
This is a typical use of the past perfect to indicate the past in the past.