What's a word to describe an apartment when its owners are on vacation?

Solution 1:

I would use the word unattended, as opposite to attended.
From the Vocabulary.com Dictionary:

having a caretaker or other watcher

When I went on vacation, thieves climbed into my unattended apartment.

Solution 2:

I'd use vacant.

  1. having no occupant; unoccupied: no vacant seats on this train.
  2. not in use: a vacant room.