How do you get angry grandmas in cookie clicker?
Get atleast 7 grandmas and 7 grandma types.
Get the Bingo center/Research facility and buy the new upgrades from that. It will start the grandma apocalypse.
If you already have 7 types of grandmas, then make sure you're waiting long enough, the bingo center takes time to research, approx. 30 minutes, but it can be reduced with the ascension upgrade "Persistent Memory".