Does playing as different heroes change anything?
Each hero has a unique weapon that only he can use:
Ratchet: the doppelbanger same as the Decoy Glove from the first and second games throw out a dummy to distract the enemies
Clank: zoni blaster slows down time
Qwark: quantum deflector is an ultimate defense and great for rushing in to smash everything
Nefarious: cloaker lets you become invisible