Is this a virus: Tons of people talking out of nowhere when playing a game
Opensubscriber.com itself seems to be safe; the problems lie in the sites it links to:
<script type="text/javascript" src="http://ads.clicksor.com/showAd.php?nid=1&pid=150886&adtype=1&sid=226316"></script>
Clicksor has been reviewed as having viruses by both WOT and McAfee SiteAdvisor reviewers.
<noscript><a href="http://www.yesadvertising.com">affiliate marketing</a></noscript>
Yesadvertising has also been reviewed as having viruses by both WOT and McAfee SiteAdvisor reviewers.
You might want to just reformat, this may be a pain without backups but after reading what horatio said I would definitely Nuke my install. I also noticed that the first two times I tried loading the site our Palo Alto PA2020 blocked it. I didn't think much of it since this firewall is pretty hardcore and sometimes a little overzealous, and nothing looked out of place after I got on there. But with a service like Clicksor you can't know for sure what the ad company may have injected in their banners. Sorry if this isn't the answer you are looking for but it is the only way to know you for sure that your PC is clean.
EDIT: Read this.
Con
Possibility of displaying irrelevant ads[9]
Accept English sites only
Slow loading time of ads
Serving ads containing Malware and Trojans