"Too much pills and liquor" or "Too many pills and liquor"?
If you wanted to take the preferred grammatical form, I would go with WS2's answer:
Too many pills and too much liquor.
However, as Barmar mentions in the comments, pills and liquor can be informally used as one big non-quantitative noun, and therefore much would be the correct word to use:
Too much pills and liquor.
I would say Too many pills and too much liquor. I think you will find that to be the preferred grammatical form.