Mavericks Mail will not save preferences

Solution 1:

Make sure that all the permissions are correct on your home folder.
You can use the ACL tool on the Recovery HD to do this:

  1. Boot into the Recovery HD using ⌘R.
  2. Run resetpassword in Terminal (available from Utilities → Terminal).
  3. Select your account from the drop-down list.
  4. Click the Reset button for Reset Home Directory Permissions and ACLs.