Invalid Mutex directory in argument file:${APACHE_LOCK_DIR}

Solution 1:

I ran into this once and this worked for me:

source /etc/apache2/envvars 
apache2 -V
sudo service apache2 restart

I haven't had the problem since.

Solution 2:

That looks like you tried to start Apache by running something like

apache2

That doesn't work. Use

sudo service apache2 start

instead.