How do I pick up the shrine orb in Kakariko Village?
You have to complete all of the other side quests in Kakariko Village first, then you will unlock a new sidequest that will let you use the orb.
You need to complete these sidequests first:
- Flown The Coop
- Arrows of Burning Heat
- By Firefly's Light
- Find the Fairy Fountain
Note that you can only use the orb in Kakariko on the pedestal. If you try to use another one, it will not work:
(Image source: 4chan)