SQLite Performance Benchmark -- why is :memory: so slow...only 1.5X as fast as disk?
It has to do with the fact that SQLite has a page cache. According to the Documentation, the default page cache is 2000 1K pages or about 2Mb. Since this is about 75% to 90% of your data, it isn't surprising that the two number are very similar. My guess is that in addition to the SQLite page cache, the rest of the data is still in the OS disk cache. If you got SQLite to flush the page cache (and the disk cache) you would see some really significant differences.
My question to you is, What are you trying to benchmark?
As already mentioned, SQLite's :memory: DB is just the same as the disk-based one, i.e. paged, and the only difference is that the pages are never written to disk. So the only difference between the two are the disk writes :memory: doesn't need to do (it also doesn't need to do any disk reads either, when a disk page had to be offloaded from the cache).
But read/writes from the cache may represent only a fraction of the query processing time, depending on the query. Your query has a where clause with two large sets of ids the selected rows must be members of, which is expensive.
As Cary Millsap demonstrates in his blog on optimizing Oracle (here's a representative post: http://carymillsap.blogspot.com/2009/06/profiling-with-my-boy.html), you need to understand which parts of the query processing take time. Assuming the set membership tests represented 90% of the query time, and the disk-based IO 10%, going to :memory: saves only those 10%. That's an extreme example unlikely to be representative, but I hope that it illustrates that your particular query is slanting the results. Use a simpler query, and the IO parts of the query processing will increase, and thus the benefit of :memory:.
As a final note, we've experimented with SQLite's virtual tables, where you are in charge of the actual storage, and by using C++ containers, which are typed unlike SQLite's way of storing cell values, we could see a significant improment in processing time over :memory:, but that's getting of topic a bit ;) --DD
PS: I haven't enough Karma to comment on the most popular post of this thread, so I'm commenting here :) to say that recent SQLite version don't use 1KB pages by default on Windows: http://www.sqlite.org/changes.html#version_3_6_12