What does the phonetic symbol after the comma mean here?
I was checking the Pronunciation of enshrine from ODO which lists:
Pronunciation: /ɪnˈʃrʌɪn, ɛn-/
Does it mean that there are two different accepted pronunciations?
yes. it can either be /ɪnˈʃrʌɪn/ or /ɛnˈʃrʌɪn/. Usually, the more common is listed first.