Can't access domain internally via public IP address [duplicate]

I have a dedicated server running Proxmox and a VM inside Proxmox running Debian 7 (Wheezy).

As I only have one IP address, I'm using iptables to forward ports to the VM.

My /etc/network/interfaces:

# The loopback network interface
auto lo
iface lo inet loopback

# For routing
auto vmbr1
iface vmbr1 inet manual
    post-up /etc/pve/kvm-networking.sh
    bridge_ports dummy0
    bridge_stp off
    bridge_fd 0


# vmbr0: Bridging. Make sure to use only MAC adresses that were assigned to you.
auto vmbr0
iface vmbr0 inet static
    address 91.121.<redacted>
    netmask 255.255.255.0
    network 91.121.<redacted>.0
    broadcast 91.121.<redacted>.255
    gateway 91.121.<redacted>.254
    bridge_ports eth0
    bridge_stp off
    bridge_fd 0

iface vmbr0 inet6 static
    address 2001:41D0:1:A790::1
    netmask 64
    post-up /sbin/ip -f inet6 route add 2001:41D0:1:A7ff:ff:ff:ff:ff dev vmbr0
    post-up /sbin/ip -f inet6 route add default via 2001:41D0:1:A7ff:ff:ff:ff:ff
    pre-down /sbin/ip -f inet6 route del default via 2001:41D0:1:A7ff:ff:ff:ff:ff
    pre-down /sbin/ip -f inet6 route del 2001:41D0:1:A7ff:ff:ff:ff:ff dev vmbr0

auto vmbr2
iface vmbr2 inet static
    address 10.21.21.254
    netmask 255.255.255.0
    bridge_ports none
    bridge_stp off
    bridge_fd 0
    pre-up echo 1 > /proc/sys/net/ipv4/ip_forward
    pre-up iptables-restore < /etc/iptables.rules

The iptable rule looks like so (along with more ports, but they all look the same more or less):

-A PREROUTING -i vmbr0 -p tcp -m tcp --dport 80 -j DNAT --to-destination 10.21.21.4:80
-A POSTROUTING -s 10.21.21.0/24 -o vmbr0 -j MASQUERADE

There is a site running using Node.js, proxied by Nginx all running inside the VM.

My Nginx configuration is:

upstream node {
    server 127.0.0.1:4567;
}
server {
    listen 80;
    server_name myDomain.co.uk;
    location / {
        proxy_pass http://node;
        proxy_next_upstream error timeout invalid_header http_500 http_502 http_503 http_504;
        proxy_redirect off;
        proxy_buffering off;
        proxy_set_header        Host            $host;
        proxy_set_header        X-Real-IP       $remote_addr;
        proxy_set_header        X-Forwarded-For $proxy_add_x_forwarded_for;
        proxy_http_version 1.1;
        proxy_set_header Upgrade $http_upgrade;
        proxy_set_header Connection "Upgrade";
    }
}

When pinging my domain, it works fine:

PING myDomain.co.uk (my.ip.address) 56(84) bytes of data.
64 bytes from myHostName.eu (my.ip.address): icmp_req=1 ttl=64 time=0.282 ms
64 bytes from myHostName.eu (my.ip.address): icmp_req=2 ttl=64 time=0.275 ms
64 bytes from myHostName.eu (my.ip.address): icmp_req=3 ttl=64 time=0.284 ms
64 bytes from myHostName.eu (my.ip.address): icmp_req=4 ttl=64 time=0.339 ms

However when trying cURL, it refuses to connect.

curl --verbose myDomain.co.uk
* About to connect() to myDomain.co.uk port 80 (#0)
*   Trying my.ip.address...
* Connection refused
* couldn't connect to host
* Closing connection #0
curl: (7) couldn't connect to host

Edit:

I've changed the rules to (as per @FrederikNielsen's advice):

-A PREROUTING -d my.ip.address/32 -p tcp -m multiport --dports 80 -j DNAT --to-destination 10.21.21.4
-A POSTROUTING -s 10.21.21.0/24 -o vmbr0 -j MASQUERADE
-A POSTROUTING -s 10.21.21.0/24 -d 10.21.21.4/32 -p tcp -m multiport --dports 80 -j SNAT --to-source my.ip.address

But still no luck. The error has changed to:

* About to connect() to myDomain.co.uk port 80 (#0)
*   Trying my.ip.address...
* Connection timed out
* couldn't connect to host
* Closing connection #0
curl: (7) couldn't connect to host

You are going to do some hairpin NAT'ing.

This question has a pretty good accepted answer that explains how to do it.

Another solution could be to use split-horizon DNS setup, but this involves a bit more setup than hairpin NAT'ing.

Update:

-A PREROUTING -d externalIP/32 -p tcp -m multiport --dports 80 -j DNAT --to-destination 10.21.21.4
-A POSTROUTING -s 10.21.21.0/24 -o vmbr0 -j MASQUERADE
-A POSTROUTING -s 10.21.21.0/24 -d 10.21.21.4/32 -p tcp -m multiport --dports 80 -j MASQUERADE

Update #2:

-A PREROUTING -d externalIP -p tcp --dport 80 -j DNAT --to-destination 10.21.21.4
-A POSTROUTING -s 10.21.21.0/24 -d 10.21.21.4 -p tcp --dport 80 -j SNAT --to-source routerInternalIP