Can I bind multiple attacks from a class to hotkeys?
In some of the earlier beta screenshots, a Monk was shown with two spirit generators (blue spells) bound to Mouse 1 and 2. Is this functionality totally gone or can you mix up your abilities and keybinds?
Yes, you need to enable "Elective Mode" in the options. This will allow you to assign any skill you have unlocked to any slot you have unlocked.
Here's a more detailed explanation.