Best method for reading newline delimited files and discarding the newlines?

lines = open(filename).read().splitlines()

Here's a generator that does what you requested. In this case, using rstrip is sufficient and slightly faster than strip.

lines = (line.rstrip('\n') for line in open(filename))

However, you'll most likely want to use this to get rid of trailing whitespaces too.

lines = (line.rstrip() for line in open(filename))

What do you think about this approach?

with open(filename) as data:
    datalines = (line.rstrip('\r\n') for line in data)
    for line in datalines:
        ...do something awesome...

Generator expression avoids loading whole file into memory and with ensures closing the file

for line in file('/tmp/foo'):
    print line.strip('\n')

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