Can I kill off squadmates?

Only two squadmates can really die in Mass Effect 3 — and only because of in-game choices you make along the way. James isn't one of them.

The two squadmates that can die are:

• Tali: she will commit suicide if you side with the Geth
• Ashley or Kaidan (whichever survived ME1): your squad will shoot them if you can't talk them down at the part where you kill Udina.

!!!!!!!MAJOR SPOILERS IN LINK!!!!!!!

This link has a list of characters that can die in ME3, I am not sure if this list it 100% finished or accurate, but I fear James never even makes an appearance on the page. You may be stuck with him eternally.