"Difference in" or "difference to"?
I personally would use;
To, if you were saying the university degree would change the type of work you did.
&
In, if you were saying the university degree would change the way you worked in that career.
I personally would use;
To, if you were saying the university degree would change the type of work you did.
&
In, if you were saying the university degree would change the way you worked in that career.