System extension is checked and greyed out

What does it mean if under System Preferences->Security & Privacy system software is checked and greyed out?

Are they activated by default without actually activating them in the Security & Privacy settings in the first place?

Let's say I only want to activate the Karabiner system extension (see Screenshot) but not the greyed out ones which are checked by default? How would I do that?

Some more information:

Executing sudo systemextensionsctl list

Here it states that e.g. GlobalProtect is activated waiting for user. What does this even mean?

Solution 1:

The state activated waiting for user means that the system extension has been loaded onto the system and ready to be enabled, however the user has not yet allowed it to be enabled.

Normally you would open System Preferences > Security & Privacy and in the General tab click the Allow button to enable the system extension.

After the user has allowed the extension to run, the state listed by systemextensionsctl should change to be activated enabled.