Epson Perfection V500 scanner not working with Image Capture on macOS 11.5 (Big Sur)
Solution 1:
I found that this is something to do with Gatekeeper, which is designed to ensure that only trusted software runs on your Mac.
I was able to resolve the problem by running the following command in the Terminal:
xattr -rd com.apple.quarantine /Library/Image\ Capture/Devices/EPSON\ Scanner.app
After that the scanner works fine!