What tools allow for creation and editing of a PDF document on OS X?

Solution 1:

I use Adobe InDesign for this kind of thing... more flexible than AcrobatPro. Allows total control over what you import into the pdf (text,images, other pdfs, etc.) and the ability to create clickable TOCs. If you are going to do a lot of this, or a lot of print, it is worth the investment.

Solution 2:

You can actually merge multiple PDFs right from Preview.app. Just open two PDFs in two separate windows, turn on the sidebars, and drag pages from one sidebar to the other. This won't provide you with a table of contents, but you can always just make something in TextEdit, export it as a PDF, then add it to the beginning of the document.