My two miners in Dwarf Fortress dropped their pickaxes
Couple of options:
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Assign two other dwarves the mining labor, they should go grab the picks. If so, then something has happened to your miners - perhaps they're injured somehow?
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Make sure the picks are forbidden/marked for dumping or smelting or something.
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Make sure the miners didn't get activated as soldiers with kits that prevent picks.
As a final option you can try building a weapons stockpile and get the picks moved there - if they don't go, then something is preventing dwarves from interacting with the picks themselves.