Quicklook is broken in Lion
Solution 1:
This sounds like a bug; you can report it at bugreporter.apple.com with an Apple ID and password.
Can you reproduce the problem, then check for new error messages in /Applications/Utilities/Console.app? There's a small chance that this will indicate the source of the problem.
Solution 2:
You might see a message in the console like this:
com.apple.quicklook.32bit[22808]): Job appears to have crashed: Abort trap: 6
You should file as bneely says.
Have you tried the usual stuff of repairing permissions, restarting etc.
Also, if you file a report, you should include your system.log (/var/log) and Apple System Profile report (About this Mac > More Info > System Report > save....)