Is it possible to split VirtualBox Hard Drive to multiple volumes?

VirtualBox hard drive usually has one or a few files when you create a drive. I think it is good because you manage only a few files. However, I have out of space of my drive. Is it possible to span over other volume like in VM player?

Yes it is possible, though you need to use the VMDK disk format.

VBoxManage clonehd disk.vdi disk.vmdk --format VMDK --variant Split2G

This will create disk.vmdk (text file) along with a number of disk-sXXX.vmdk (data files). You should point your virtual machine to use the disk.vmdk file.

Just an idea, what if you used the command:

vboxmanage clonehd hd1.vdi hd2.vmdk --format VMDK --variant Split2G --type normal --remember