Should I burst wrinklers before harvesting Bakeberries?

Solution 1:

No, you don't have to

Wrinklers are not affecting CPS, they are withering it, so it doesn't affect the payout of Bakeberries, Chocoroots, Crumbspores, Doughshrooms and other plants.

There are at least three other values that rely on current CPS, one of them being the price of The Golden Switch. It requires a one hour worth of cookie production, and it stays the same going from 0 up to 12 wrinklers.

Note, however, that CPS is temporarily changed by Golden/Wrath Cookie effects; you may want to time your popping of Bakeberries after getting, say, Frenzy (Golden Cookie effect, x7) or Elder Frenzy (Wrath Cookie, x666) multiplier.