Is there any strategy to 2048 Numberwang?
Solution 1:
Yes, it's like regular 2048 but a bit silly.
If you ignore the randomly changing numbers, the occasional shinty-six, and "that's numberwang", it actually plays just like 2048. You can and should ignore the numbers on the pieces- use the colour of the backgrounds instead.
There are a few differences. Most notably, tiles have a 2.5% chance of merging even if their value is not the same. This makes the game significantly easier than real 2048.
Solution 2:
All you need to do is to use the same space management strategy that you'd use in 2048. I pick a corner (usually upper-right), and take turns alternating a bunch of right keys followed by a bunch of up keys, letting the large values accumulate in the upper-right corner. If you get "stuck", then usually a down-up, left-right, or down-right-up button combination usually gets things flowing again; once you practice a bit, you'll get a feel for which to use.
I've already gotten a score of over 200,000 points, which was actually my first run, even. If you were to watch me play, it'd appear largely random, but it's not--I'm corralling the larger-colored squares to one corner to make room for the others. Every once in a while, you'll need to slow down and merge some colored blocks together, but that's more an exception than a rule.
This is what it should look like most of the time: