How to describe someone whose voice or way of talking creates an anxious or uncomfortable feeling in others?

I described someones voice as being shrill but I think that relates to the voice being particularly high pitched.

If when someone speaks and it invokes an uneasy feeling in others, how would you describe it? The uneasy feeling isn't necessarily from what they are saying but rather the tone, pitch, repetitiveness, etc.

I could generalize and say they are annoying or irritating but that isn't necessarily the case. Is there a word that is more accurate for this?

So if someone talking can be uncomfortable to listen to how would you describe their voice?

Example use could be:

  • Blimey, your voice is quite word here
  • Woah, be quiet for a second, when you speak you're quite word here

Solution 1:

Consider grating

Sounding harsh and unpleasant: her high, grating voice

Also strident

Loud and harsh; grating: his voice had become increasingly sharp, almost strident

Oxford Dictionaries Online

And if you want a simile, you could say

His voice is like fingernails on a chalkboard.

Solution 2:

"Distressing": causing anxiety, sorrow or pain; upsetting.

"Unsettling": causing one to feel anxious or uneasy; disturbing.

"Agitating": make (someone) troubled or nervous.

Solution 3:

I like unnerving.

making one feel worried or uncomfortable

Example (Telstra's phone alarm service put to sleep):

You rang the number, booked a time, then were rudely awoken from your blissful slumber by that lady with the annoying and slightly unnerving voice that sounded like a computer.