Can items affect my chances of finding an angel room?

In Binding of Isaac, I would like to know if there are any specific items that lower chances of finding an angel room.

I know that taking deals with the devil does, but how about specific items?

Solution 1:

In the Binding of Isaac there are no items dedicated to lowering your angel room chance. Like you said the only way to lower the chance of finding an angel room is by taking a deal with the devil.

There are a few items and actions that you can use to increase your angel room chance but there are no ways to lower the chance, possibly due to the ease of completely removing your chance of finding one by taking a deal with the devil.

Source: Binding of Isaac Wiki