Is there a surefire way to find a space anomaly?

Solution 1:

Space anomalies are really small (compared to other objects in space, like planets or moons), and unlike the space station which is automatically highlighted when you enter the system, anomalies are not highlighted right away. This makes it really easy to overlook. However, if you use your scanner in the system, it should find the space anomaly for you and display a message ("Space Anomaly Located" or something similar), which then adds a waypoint to show you where in the system it is.

As far as I can tell, there is no way to tell if a system will have an anomaly before warping to it.