Writing then reading in-memory bytes (BytesIO) gives a blank result

You need to seek back to the beginning of the file after writing the initial in memory file...

myio.seek(0)

How about we write and read gzip content in the same context like this?

#!/usr/bin/env python

from io import BytesIO
import gzip

content = b"does it work"

# write bytes to zip file in memory
gzipped_content = None
with BytesIO() as myio:
    with gzip.GzipFile(fileobj=myio, mode='wb') as g:
        g.write(content)
    gzipped_content = myio.getvalue()

print(gzipped_content)
print(content == gzip.decompress(gzipped_content))