How do I get rid of Zenyatta's Orb of Discord?

Solution 1:

As the other answers have said, killing the Zenyatta removes the orb, as does Recalling with Tracer or going invulnerable as Reaper (Wraith Form) or Mei (Cryo-Freeze).

Additionally, Zarya's Projected Barrier and the personal Barrier both remove the Discord Orb, as far as I know. You can call out to an allied Zarya or play her yourself to remove it.

This one is the most situational, but using Self-Destruct on D. Va, getting your mech killed, or calling down a mech, will remove the discord orb from you.

LOS'ing the Zenyatta is the most effective and reliable strategy, however.

Solution 2:

According to the wiki,

The orb of discord returns after 3 seconds if not in vision.

So to get rid of it, you can run out of his line of sight for 3 seconds. Alternatively dying also removes the orb of discord, but is somewhat counter-productive. Also, if you kill the Zenyatta, the orb will go away, though it can be risky since you will take extra damage while fighting him.

Note: An orb of discord cannot be placed on someone behind a shield, so if you stay behind one, you won't have to worry about getting one.

Also, as @uni and @yuuki mentioned, some abilities can remove the orb from you.

Solution 3:

Tracer's Recall ability removes Zenyatta's Orb of Discord and, technically, Mei's Ice Wall can remove it by breaking line-of-sight. Reaper's Wraith Form will also remove Orb of Discord.