What Is The Best Weapon (Base Damage Stat)?

Solution 1:

The Big Boy is with 468 base damage and 8.1 damage per second

Solution 2:

A Neverending Laser Musket can do an arbitrarily large amount of damage if you crank it long enough.

Per Nukapedia:

as the musket uses its "clip" to store the crank charge, and this mod sets the clip size to the amount of ammo in your inventory, the mod effectively removes the crank limit. Since the damage of the weapon is based on how many cranks you can give it, this gives that single shot a devastating amount of damage. For example, at 200 cranks, a single shot can do about 30,000 damage.