Mac OS software for periodical work break
Dejal Time Out supports both "microbreaks" and regular breaks.
AntiRSI is another option.
AntiRSI is a program for Mac OS X that helps prevent RSI (repetitive strain injury) and other computer related stress. It does so by forcing you to take regular breaks, yet without getting in the way. It also detects natural breaks so it won't force too many breaks on you.
MacBreakZ is commercial software that can tell you what to do in your breaks.