What is the correct positioning of "Please" in a sentence or indeed is there one?

Solution 1:

There are four places to put the please in that sentence.

Please, can you help me with this question?

Can you please help me with this question?

Can you help me, please, with this question?

Can you help me with this question, please?

Note that of the four, the second is the only one that isn't usually set off by commas.

Solution 2:

This is mostly a matter of choice. I would think that putting "please" at the beginning of a question would make it more polite. None of them are wrong at least.