How do I play against Handlock?

There are a few tips you need to know in order to beat Handlock, first if you play shaman, there are some key cards for this match-up and hopefully they are excellent for other match-ups too:

• Play with Hex x2 to remove those nasty giants/drakes/ancient watcher, that will help you to keep tempo against those strong minions.
• Play with Earth Schock x2 to go through the taunts when you want to go for face and finish your opponent, AND to explode the Twilight Drakes, whatever hp amount he has, this spell will kill him (the drake is a 4/X, after silence it is a 4/1 and then there is the 1 damage).

For the neutral cards : - The Black Knight, free removal of any taunted creature - Ironbeak Owl, for the silence on boosted giants, annoying taunts - Big Game Hunter, can kill any giant and Alexstrasza - Deathrattle or divine shield minions to keep something on board after the Hellfire/Shadowflame (with cards like Harvest Golem, Nerubian Egg, Cairne Bloodhoof, Sylvanas,..)

Now for the tips with every class :

If you dealt with ancient watchers/drakes/mountain giants from early game you will still have to deal with the molten giants when his HPs get low, and dealing with those on board will often result in you losing the game. So, the best way to deal with them is to prevent him from playing them. Molten giant costs 20mana at start, and the cost is reduced by one for each HP the hero is missing. You need to keep track of that, as if he is at 14hp or less he can play Molten x 2 (4mana x 2) and sunfury protector (2mana) for example.

Therefore you need to keep him at 15+ hp, and then burst him to 0 in one turn, that is the best scenario. Let's take the example of the shaman again :

• Doomhammer + Rockbiter Weapon ( (2 + 3) * 2 = 10dmg ) + anything to deal the 5 remaining (Lightning bolt, minions on board, lava burst)
• Doomhammer + (Rockbiter Weapon weapon x 2) = (2 + 3 + 3) * 2 = 16dmg
• Al'Akir + Rockbiter Weapon weapon = (3 + 3) * 2 = 12dmg + lightning bolt/lava burst/minions
• having Wrath of Air Totem (spell dmg totem) up : Lava Burst x 2 + Lightning Bolt = 16dmg

And of course there are a lot of other combos.

To end, let's talk about the easiest match-up against Handlock: Hunter, both hero powers go in the same direction, which is making the Warlock lose health. Strong removal with Freezing Trap making them harder to play and losing tempo, Hunter's Mark to remove someone, and Kill Command for high damage. And the best, Hunter has a lot of burst options to remove those 15 last hit points. Thanks to all this options, when you look at Handlock players' statistics and trackers, they usually have around 35% winrate only against Hunter.