In-game sound gone after playing a while

After starting the game and playing for a while, suddenly the screen flicked, there's another white cursor, and the sound is gone, all of it.

There seems to be a lot of factors that caused this to happen: fast travel, fighting, strolling, etc. So maybe I can say it is affected by the in-game time? Please help, it's really annoying to keep restarting the game every time it occurs. Thanks in advance.

Does sound still play from other programs? Check if eg. Youtube works - if not, it's that your computer processor got "into delay" and somehow left the sound behind, or stopped the sound because it was too loud ( = are you using headphones?).

If other sound sources work well, it's a problem of Skyrim - a bug/glitch or something. You could try reinstalling the game if it really annoys you