Is it: My apples and orange are/is wrong?

Simple question:

My apples and orange are wrong

or

My apples and orange is wrong

I am not a native English speaker, and I am having some trouble choosing between plural are or singular is for that kind of example.

It's hard to conceive of a situation in which apples and oranges could be wrong, but let's suppose there is.

Assuming you really mean apples (plural) and orange (singular), the first construction is correct.

My apples and orange are wrong.

You are speaking of multiple things, and even if both were singular

My apple and orange are wrong.

the copula (verb of being) would still be plural.