Is it possible to run SimCity on two monitors?

Nvidia Surround: You cannot run with two monitors, you must use 3 monitors.

ATI eyefinity: You can use two monitors, however, users reported that it was very annoying because the center of the screen was the border of the 2 monitors. They strongly recommended 3 monitors so this would not occur.

There are YouTube videos demonstrating how to set these up.

Not being able to try either of these (for technical reasons regardless of the 4 monitors I am staring at), this is the best answer I can give.

Alternatives
If you are after more real estate for playing, there are 27" and 30" monitors that support larger resolutions of 2560 wide.

Dell has an ultrawide 29" which is the same resolution width as the 30", just not as high. The price is up to 1/4 of the price of the 30". It is worth a look.

Because you may have to get an additional graphics card to support 3 monitors, a larger monitor could be the cost effective solution.

SimCity does not have native multi-monitor support, so will not utilise two or more screens without the use of third party technologies like Eyefinity or Nvidia surround (or equivalent technologies or devices) to allow the use of ultra wide (or ultra high, depending on the orientation of your monitors) resolutions.