Is it possible to set borderless window mode?
Use the following AutoHotKey Script:
^!a::
WinSet, Style, -0xC00000, a
WinMove, a, , 0, 0, 1680, 1050
return
When you press ctrl+alt+a it will make the currently active window borderless.
Replace 1680 and 1050 with the size you want the window to be.
Mass Effect does not come with any support for borderless window mode. The only way to do so is to use a third party utility such as ShiftWindow.
There are also ways to do it with autohotkey