How to calculate an angle from points?

You want the arctangent:

dy = ey - cy
dx = ex - cx
theta = arctan(dy/dx)
theta *= 180/pi // rads to degs

Erm, note that the above is obviously not compiling Javascript code. You'll have to look through documentation for the arctangent function.

Edit: Using Math.atan2(y,x) will handle all of the special cases and extra logic for you:

function angle(cx, cy, ex, ey) {
  var dy = ey - cy;
  var dx = ex - cx;
  var theta = Math.atan2(dy, dx); // range (-PI, PI]
  theta *= 180 / Math.PI; // rads to degs, range (-180, 180]
  //if (theta < 0) theta = 360 + theta; // range [0, 360)
  return theta;
}

Runnable version of Christian's answer.

function angle(cx, cy, ex, ey) {
  var dy = ey - cy;
  var dx = ex - cx;
  var theta = Math.atan2(dy, dx); // range (-PI, PI]
  theta *= 180 / Math.PI; // rads to degs, range (-180, 180]
  return theta;
}
function angle360(cx, cy, ex, ey) {
  var theta = angle(cx, cy, ex, ey); // range (-180, 180]
  if (theta < 0) theta = 360 + theta; // range [0, 360)
  return theta;
}

show("right", 0, 0, 1, 0);
show("top right", 0, 0, 1, 1);
show("top", 0, 0, 0, 1);
show("top left", 0, 0, -1, 1);
show("left", 0, 0, -1, 0);
show("bottom left", 0, 0, -1, -1);
show("bottom", 0, 0, 0, -1);
show("bottom right", 0, 0, 1, -1);

// IGNORE BELOW HERE (all presentational stuff)

table {
  border-collapse: collapse;
}
table, th, td {
  border: 1px solid black;
  padding: 2px 4px;
}
tr > td:not(:first-child) {
  text-align: center;
}
tfoot {
  font-style: italic;
}

<table>
  <thead>
    <tr><th>Direction*</th><th>Start</th><th>End</th><th>Angle</th><th>Angle 360</th></tr>
  </thead>
  <tfoot>
     <tr><td colspan="5">* Cartesian coordinate system<br>positive x pointing right, and positive y pointing up.</td>
  </tfoot>
  <tbody id="angles">
  </tbody>
</table>
<script>
function show(label, cx, cy, ex, ey) {
  var row = "<tr>";
  row += "<td>" + label + "</td>";
  row += "<td>" + [cx, cy] + "</td>";
  row += "<td>" + [ex, ey] + "</td>";
  row += "<td>" + angle(cx, cy, ex, ey) + "</td>";
  row += "<td>" + angle360(cx, cy, ex, ey) + "</td>";
  row += "</tr>";
  document.getElementById("angles").innerHTML += row;
}
</script>

If you're using canvas, you'll notice (if you haven't already) that canvas uses clockwise rotation^(MDN) and y axis is flipped. To get consistent results, you need to tweak your angle function.

From time to time, I need to write this function and each time I need to look it up, because I never get to the bottom of the calculation.

While the suggested solutions work, they don't take the canvas coordinate system into consideration. Examine the following demo:

Calculate angle from points - JSFiddle

function angle(originX, originY, targetX, targetY) {
    var dx = originX - targetX;
    var dy = originY - targetY;

    // var theta = Math.atan2(dy, dx);  // [0, Ⲡ] then [-Ⲡ, 0]; clockwise; 0° = west
    // theta *= 180 / Math.PI;          // [0, 180] then [-180, 0]; clockwise; 0° = west
    // if (theta < 0) theta += 360;     // [0, 360]; clockwise; 0° = west

    // var theta = Math.atan2(-dy, dx); // [0, Ⲡ] then [-Ⲡ, 0]; anticlockwise; 0° = west
    // theta *= 180 / Math.PI;          // [0, 180] then [-180, 0]; anticlockwise; 0° = west
    // if (theta < 0) theta += 360;     // [0, 360]; anticlockwise; 0° = west

    // var theta = Math.atan2(dy, -dx); // [0, Ⲡ] then [-Ⲡ, 0]; anticlockwise; 0° = east
    // theta *= 180 / Math.PI;          // [0, 180] then [-180, 0]; anticlockwise; 0° = east
    // if (theta < 0) theta += 360;     // [0, 360]; anticlockwise; 0° = east

    var theta = Math.atan2(-dy, -dx); // [0, Ⲡ] then [-Ⲡ, 0]; clockwise; 0° = east
    theta *= 180 / Math.PI;           // [0, 180] then [-180, 0]; clockwise; 0° = east
    if (theta < 0) theta += 360;      // [0, 360]; clockwise; 0° = east

    return theta;
}