Windows 8: Ethernet traffic blocks mouse

Your mouse is the M-RCE95 aka. Cordless Desktop EX 100. It has no driver on Logitech for either Windows 7 or 8, so it should work with the generic Windows driver.

This is unlikely to be a software problem, unless Windows is corrupted. To check for such corruption, however unlikely, use the sfc /scannow command.
Detailed description can be found in the article :
How to Run "SFC /SCANNOW" Command at Boot or in Windows 8 and 8.1.

As you have tried getting the mouse as physically close to the USB receiver as possible, and also further away, and as you use a USB2 port, this is probably not a problem of interference or of port incompatibility. The cause can only be interference if your environment is heavily saturated with wireless radiation, which I hope is not the case.

This leaves hardware. Try to exchange the mouse, if still under warranty, or try a wireless mouse of another model. If no wireless mouse will work in your environment, then use a wired one, but better also in this case check your environment for radiation hazards.

You are not alone in this.
http://answers.microsoft.com/en-us/windows/forum/windows_7-hardware/windows-7-64-bit-mouse-freezesstutters-multiple/0dbeaa4a-1341-41c4-932c-3fc2c524b135?page=1&tm=1433162678183
Here are a few things you can try.

1. Interference

Believe it or not, the ethernet jack can interfere with the usb mouse receiver and reduce its range, during a period of high network activity. To test this get a usb extension, maybe a 3 or 6 footer, and move the mouse receiver away from the PC.

2. Software Incompatability

Many users have reported this to be caused by a specific program.
Skype and malwarebytes were two of them.
To test, shut down any non necessary background programs/services one by one.
Do this while experiencing the issue.

I'm resurrecting this old thread in case its useful for others. I've had problems with unresponsive mice and my Intel D975XBX2 motherboard for around three to four years. I tried four different mice across Windows 8 through to 10 and never found a solution... until today.

The solution was to disable the Ethernet Adaptor as shown here. On doing so my mouse instantly became fully responsive.

I don't use the Ethernet port as I have a WiFi wireless adaptor. If you use your Ethernet port I suggest temporarily disabling the Ethernet adaptor to see if mouse performance improves. If it does then at least you know the cause of the issue.

I always felt this was a problem with (probably Microsoft) software and there was nothing wrong with hardware. It looks like that was the case. Sorry to resurrect an old thread but I hope its useful for others.