What's the best way to harvest organs from the Infernal Machine?

Solution 1:

I just did 3 complete sets last night with my friends and here are some general tips to do this.

1. Depending on your dps, you may want to prepare some champions/elites near waypoints to 'restock' up on NV in between boss fights. Since you NEED to maintain 5 stacks for any chance of the organ drop at all.

2. You'll want to fight on the highest MP you can tolerate at since each additional level grants a 10% chance of dropping an organ.

3. You can open up all 3 portals at the same time, you don't have to worry about portal placement like in d2 (raise your hand if you've borked yourself like I did by opening up 2 portals at the same place in D2), each portal shows up in a prearranged position. They are arranged in a triangle. When you use the inferno machine in the shack, one random portal will open up in one of the locations. I recommend just opening 1 at a time though, in case you can't handle the boss on that MP or if the game crashes, so you don't waste 3 inferno machines.

4. Specific portal boss strategies:

   • Top portal: The Realm of Chaos - Ghom and Raknoth(drops Devil's Fang). Go after Ghom first as he'll spawn his usual cloud of annoying stuff, and Raknoth will teleport around quite often during the fight so its easier to kill Ghom first.
   • Left portal: The Realm of Discord - King Leoric and Mahgda (drops Writhing Spine). This fight is very annoying. Mahgda's insect swarm hurts a LOT. At the beginning of the fight, attack Mahgda first until she puts up her shield, then go after the Skeleton King. Mahgda will keep her shield up for the rest of the fight until the skeleton king dies, making her slightly less annoying. Also, she'll run around a lot, and try not to fight her while she's in a corner as she spawns arcane beams.
   • Right portal: The Realm of Turmoil - Siege Breaker and Zoltun Kulle(drops Vengeful Eye). Kill seige breaker first since ZK loves to run around a lot. When ZK puts up his annoying time bubble, make sure you lead seigebreaker out of it or your attacks will be severely slowed down.

5. Remember, these are considered full boss fights. Don't hit that resurrect button (if you are playing with friends) as you'll be kicked out of the battle. Try to get a res if possible.

Solution 2:

Yes, it's possible to open all 3 portals at the same time in the Heretic's Abode found in New Tristram. There isn't much to say about organ farming otherwise.