Is there a way to make Opera a different proxy than what is set by the system?

Append --proxy-server="ip:port" to your Opera shortcut like:

"C:\Programs\Opera\launcher.exe" --proxy-server="62.103.107.9:80"

Some Google Chrome switches work in Opera too since they use the same underlying technologie.

Further links

  • Syntax for proxy switch. Make sure to include the quotes and the port
  • Full list of Chromium switches