Create a shortcut for Notepad++ to reopen a closed tab?

I have successfully tested the following solution: define this AutoHotKey macro:

SendMode Input                ;just to set up preferred method of sending hotkeys
SetTitleMatchMode, RegEx      ;from now on, windows titles are matched by regex

#IfWinActive Notepad\+\+      ;(open block) the following hotkeys work only in N++
+^t::Send !f1                 ;desired hotkey: Ctrl+Shift+T sends Alt+F, 1
^w::Send ^{F4}                ;bonus: Ctrl+W sends Ctrl+F4 (close file convention)
#IfWinActive                  ;(close #IfWinActive block)

do not forget to run AutoHotKey as administrator.

Using the AHK you can achieve many useful things in N++ and all other applications.

As of now, the shortcut CTRL+SHIFT+T is already the default for reopen closed tabs.

You can always use the ShortCut Mapper :