Uninstalling the default US-Qwerty keyboard layout off Windows 7

Open Control Panel then "Region and Language".

Next, go to the "Keyboards and Languages" Tab.

Simply click on any keyboard and as long as you have a secondary keyboard, you should see the option to remove.

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The key issue is that the one you want to remove cannot be the current default. Take note of the top group labeled: 'Default Input Language' and ensure that the one you want to remove is not the default. Once you correct that, the remove is no longer grayed out.