DNAT port range with different internal port range with Iptables

To answer your question, yes.

I ran a sample rule on my Debian box...

iptables -t nat -A PREROUTING -i xenbr0 -p tcp --dport 64000:65000 -j DNAT --to 172.16.10.10:61000-62000

... which produced no output, indicating success. I'm running kernel 3.16.0-4-amd64.

Checking the NAT rule via iptables -t nat -vnL PREROUTING, I see the rule is listed...

DNAT       tcp  --  xenbr0 *       0.0.0.0/0            0.0.0.0/0            tcp dpts:64000:65000 to:172.16.10.10:61000-62000

MadHatter is correct, you do not need -m multiport for port ranges, only for comma-separated lists of ports. The : is needed in order to specify port ranges for the --dport option, but a - is needed in order to specify port ranges in the DNAT target.

How well this rule will work in practice I cannot say, but theoretically it should accomplish your goal.

More information on DNAT target can be found here.

Hope this helps.