What is the most profitable farm spot or area in Inferno?
Solution 1:
Replenished Chest in Act III - The Keep Depths Level 1 (Nerfed)
This spot no longer exists as of June 9 2012, its a normal chest now.
Requirements:
You will need a high amount of magic find, and gear to kill at least normal monsters in Act III. Doing it as group (parallel searching) will increase profit dramatically because you will find the spot much faster.
Execution:
Set your checkpoint at The Keep Depth Level 2 entrance and go back to level 1. Run straight south east until you reach the chest above the first lava ground. The chance to get a chest is at about 20%, I guess. You will detect, that all other dungeon setups except that with the chest spawn can be skipped immediately. If you find elite mobs, kite them into that door in the north, and call your group in after securing the area. There are some strong spawns, like those dogs monsters (Soul Ripper) which have crazy speed, range and damage output, you might want to skip those. After you opened the chest, there will spawn monsters. Use area stuns to loot and run away with your full magic find gear.
Results:
With 200% magic find I get about one rare drop per chest with high (Act III) item level. Profit is really dependent on your luck with item stats.
Solution 2:
The Warden / Butcher in Act I - Halls of Agony Level 1-3
Requirements:
You do not need especially high amount of magic find, but a good amount of damage output (about 15k) to beat the enrage timer. If you are not able to kill Butcher solo you might want to do this with a group.
When it comes to magic find: Magic find always helps, so get as much of it as you can. But do not let it interfere with the strength of your character. If you sacrifice too much stats to get high magic find, you won't gain anything, because you will have too much troubles clearing champion packs. It's better to make yourself stronger and enable you to kill the enemies faster then.
Execution:
If you start from the beginning of quest 9 (The Imprisoned Angel, and the Leoric's Manor waypoint) and work your way down the Halls of Agony, you will usually have 5 Nephalem Valor stacks before you get to the Warden. (If not, go to the Cemetery of the Forsaken and build up the 5 stacks before facing the Warden). After the Warden, go on to the Butcher. Doing this gives you two bosses with Nephalem Valor boosted loot quite close to each other.
If you are having big problems with Act I. I suggest you go back to Act III Hell and do a couple of runs there. Remember that equipment with a level requirement of 50-55 is generally worth much more than level 60 items even if the level 60 items have quite significantly better stats.
Results:
You will never be able to find any weapons which can sell on the auction house in Act I (maybe you could get the best of the best weapons sold for like 3k-5k, but it's not worth the auction house slots), but if you are lucky you can find some quite decent armor pieces.