Testing multiple configurations of parameterizable modules in a Verilog testbench
Since $value$plusargs is evaluated at runtime, it can not be used to set parameter values, which must be done at compile-time.
However, if you use generate to instantiate multiple instances of the design with different parameter settings, you might be able to use $value$plusargs to selectively activate or enable one instance at a time. For example, in the testbench, you could use the runtime argument to only drive the inputs of a specific instance.