How to run a local script when a brick is touched?

Place the local script in StarterPlayerScripts.

I rewrote your code in a slightly better way. Place this code in the local script

Lighting = game:GetService('Lighting')

game.Workspace.Five.Touched:Connect(function(hit)
   if hit.Parent:FindFirstChild('Humanoid') then
      print('Runned')
      Lighting.inverted1.Enabled = true
      Lighting.inverted2.Enabled = true
   end
 end)

It's recommended to usegame:GetService('Service name') to use services. I also changed if hit.Parent == game.Players.LocalPlayer.Character then for if hit.Parent:FindFirstChild('Humanoid') then because it's simpler and the code runs faster than the character loads, so it gives an error and stops running. Link with GetService() API reference: https://developer.roblox.com/en-us/api-reference/function/ServiceProvider/getService