Viruses in wine? [duplicate]

No, Windows malware can't "spread" to the host Linux system.

No, Windows malware doesn't "spread" across Wine prefixes.

For both questions, a theoretical possibility is not to be ruled out, but it would mean that the malware writers would deliberately attempt to target Wine systems, which is extremely unlikely - unless you are a security researcher you don't care about this.

By nuking your .wine you should be okay.

Nota bene: Windows malware in Wine can do all sorts of bad things to files it has permissions to access, which includes your home directory. Windows malware can't spread to the Linux host, but it can nuke files in your Linux home directory.

EDIT: Of course, the likelihood of having false positives if you scan an entire Wine installation with a Windows antimalware tool is probably greater than everything else.