Generic method with multiple constraints

I have a generic method which has two generic parameters. I tried to compile the code below but it doesn't work. Is it a .NET limitation? Is it possible to have multiple constraints for different parameter?

public TResponse Call<TResponse, TRequest>(TRequest request)
  where TRequest : MyClass, TResponse : MyOtherClass

It is possible to do this, you've just got the syntax slightly wrong. You need a where for each constraint rather than separating them with a comma:

public TResponse Call<TResponse, TRequest>(TRequest request)
    where TRequest : MyClass
    where TResponse : MyOtherClass

In addition to the main answer by @LukeH with another usage, we can use multiple interfaces instead of class. (One class and n count interfaces) like this

public TResponse Call<TResponse, TRequest>(TRequest request)
  where TRequest : MyClass, IMyOtherClass, IMyAnotherClass

or

public TResponse Call<TResponse, TRequest>(TRequest request)
  where TRequest : IMyClass,IMyOtherClass